Pyruvate Dehydrogenase Complex

《英文msh詞典》Pyruvate Dehydrogenase Complex
[主題詞] Pyruvate Dehydrogenase Complex
[入口詞] Complex,Pyruvate Dehydrogenase
[入口詞] Dehydrogenase Complex,Pyruvate
[中文釋義] 丙酮酸脫氫酶復合物
[英文釋義] A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE C (LIPOAMIDE),dihydrolipoamide acetyltransferase and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phoshorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology,3rd ed)